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Metandienone Wikipedia
1‑Acetyl‑3‑pyridylmethane (also known as N‑acetyl‑3‑pyridylmethylamine)
Feature Details
IUPAC name N‑(3‑Pyridyl)methanone
Common names 1‑Acetyl‑3‑pyridylmethane, acetyl‑pyridylmethane, N‑acetyl‑3‑pyridylmethylamine
Formula C₇H₉NO₂
Molecular weight 139.15 g mol⁻¹
SMILES `CC(=O)N(C1=CN=CC=C1)`
LogP (predicted) ≈ −0.3
Melting point ~95–98 °C (approx.)
Boiling point 140–150 °C at 760 mmHg
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Key Physical Properties
Property Value Notes
Solubility in water Highly soluble (~200 mg mL⁻¹) Due to amide and tertiary amine
Density (at 20 °C) ~1.02 g cm⁻³ Approximate, measured at 20 °C
LogP (Octanol/Water) –0.4 to –0.5 Indicates hydrophilic character
Boiling point 140–150 °C (at 760 mmHg) Decreases under reduced pressure
Melting point ~-70 °C (solid-liquid transition) Low due to flexible chain
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3. Chemical & Physical Properties
Property Value / Range Notes
Molar mass 120.18 g·mol⁻¹
Density at 25 °C 0.84 g·cm⁻³ Measured in liquid state
Solubility (water) ~10–20 g·100 mL Depends on temperature
Boiling point 114–116 °C (at 1 atm) Slight variation due to impurities
Melting point -60 °C (solid-liquid transition) Not a sharp melting point, more of a glass transition
Flash point ~58 °C Lower in presence of oxidizers
Vapor pressure at 25 °C ≈0.1 kPa Indicates moderate volatility
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Practical Implications
1. Safety Considerations
Increased Flammability: The lower flash and boiling points mean that even at ambient temperatures, the compound can produce flammable vapors.
Explosion Risk: In closed systems, vapor accumulation may lead to explosions if an ignition source is present.
Oxidizer Sensitivity: Exposure to oxidizing agents or high temperatures can further reduce safety margins.
2. Operational Adjustments
Temperature Control: Maintain operating temperatures below the reduced boiling point (e.g., < 100 °C) and ensure good ventilation.
Ventilation & Vapor Management: Install adequate exhaust systems, vapor scrubbers, or inert gas blankets to mitigate vapor build-up.
Detection Systems: Deploy flammable vapor detectors with lower thresholds aligned with the new safety limits.
3. Regulatory Compliance
Re-evaluate Safety Limits: Update permissible exposure limits (PELs) and process hazard analyses accordingly.
Documentation & Training: Revise SOPs, safety data sheets, and conduct refresher training on updated risk assessments.
4. "What If" Scenario Analysis
Scenario A: 50 % Increase in the Limiting Concentration
If the limiting concentration for safe operation rises by 50 %, this suggests a more favorable (less hazardous) environment. Potential implications:
Operational Flexibility: Higher permissible concentrations reduce constraints on product formulations and process parameters.
Risk Reduction: Lower relative exposure to hazardous levels decreases probability of incidents.
Economic Impact: May allow cost savings in ventilation, monitoring, or safety equipment.
Scenario B: 50 % Decrease in the Limiting Concentration
Conversely, a 50 % reduction indicates heightened risk:
Operational Constraints: Stringent limits may necessitate redesign of processes, product reformulations, or additional controls.
Increased Safety Measures: Likely need for enhanced ventilation, stricter monitoring, personal protective equipment (PPE), and emergency protocols.
Regulatory Implications: Potentially triggers compliance with stricter occupational safety regulations.
4. Recommendations
Immediate Data Verification
- Confirm the source of the limiting concentration values.
- Cross‑check with authoritative references (e.g., OSHA, NIOSH).
Risk Assessment Updates
- If the lower value is correct, revise exposure assessments to reflect higher risk.
- Update control plans accordingly.
Safety Protocol Enhancements
- Reevaluate PPE requirements.
- Strengthen ventilation or local exhaust systems if needed.
- Ensure emergency response procedures are aligned with updated hazard levels.
Training and Communication
- Inform all personnel of any changes in exposure limits.
- Provide refresher training on safe handling practices.
Monitoring and Verification
- Increase frequency of air sampling to verify that exposure remains below the revised limit.
- Document all changes for regulatory compliance.
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Bottom‑Line
If 1 µg/m³ is the correct standard, it is significantly lower than 3 µg/m³ and indicates a higher risk.
Confirm the exact value from your official safety documentation before making any operational adjustments.
Feel free to let me know if you need help locating the source document or updating your safety procedures!
